Kisspeptin-10
Also known as KP-10 · Metastin (45-54)
Studied in small numbers of humans, usually for safety and pharmacokinetics rather than whether it works. A phase 1 result says almost nothing about effectiveness.
What it is
The minimal active fragment of kisspeptin, a hormone central to the onset of puberty and to reproductive signalling. It is a genuine and well-regarded research tool in reproductive endocrinology.
How it is thought to work
Activates the KISS1R (GPR54) receptor on GnRH neurons, triggering downstream release of LH and FSH.
What the studies found
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Well-characterised human physiology studies
Academic groups, particularly at Imperial College London, have run controlled human studies examining effects on reproductive hormones, and more recently on sexual and emotional brain processing.
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Investigated as a fertility tool
Studied as a trigger in IVF protocols, where it has been explored as a way to reduce ovarian hyperstimulation risk.
What the evidence does not show
- Human work is early-phase physiology, conducted under close clinical supervision.
- No approved indication and no phase 3 programme.
- Findings concern acute hormonal responses in controlled settings, not outcomes from ongoing use.
Reported risks and adverse effects
- Acute administration in supervised research settings has been reported as well tolerated.
- Effects on the reproductive axis are exactly the point, which makes unsupervised use of a hormone-axis modulator a meaningful risk.
- No long-term safety data.
This is a summary of what has been reported in the literature, not a complete safety profile. For anything concerning your own health, speak to a doctor.
Regulatory status
Not approved anywhere. A research compound used in academic studies.